Radiesse is a structural filler used to fill and lift areas of the face that have dropped due to aging. The result is smoothing of moderate to severe facial wrinkles and folds. The skin of the hands can be improved and volumized as well. CollagenStim Radiesse is a global rejuvenation treatment for all-over facial smoothing, hand rejuvenation, chest and décolletage smoothing, upper arm and leg skin tightening.